P069 无情的的病变
Michelle Rosario1, Emmanuelle Williams
1Penn State Hershey Medical Center, Hershey, Pennsylvania, United States.
The American journal of gastroenterology
|July 18, 2023
概括
散播性基因质可以模仿抗TNF治疗的患者的炎症性肠病 (IBD). 早期识别暴露和非典型表现对于及时治疗和改善结果至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 在全球范围内,炎症性肠病 (IBD) 的患病率正在上升.
- 免疫抑制疗法,特别是抗瘤坏死因子 (抗TNF) 药物,被广泛用于IBD管理.
- 接受免疫抑制治疗的患者有机会性感染的风险增加.
研究的目的:
- 突出了在IBD患者免疫抑制的风险,表现和传播性组织等离子体病 (DH) 的管理.
- 强调在IBD患者有异常胃肠道症状时考虑DH的重要性.
- 讨论这个人群中DH的诊断挑战和治疗策略.
主要方法:
- 一个患有性结肠炎 (UC) 的患者在infliximab治疗中呈现出一个不愈合的十二指肠的病例介绍.
- 对患者病史,临床表现,实验室发现和成像研究 (EGD,CT,EUS) 的审查.
- 诊断工作包括活检,免疫扩散检测和传染病咨询.
主要成果:
- 一名49岁的男性在Infliximab治疗中患有UC,患上了一种大型,不治愈的十二指肠,模仿IBD.
- 在排除其他病因并确定鸟类落暴露后,诊断出传播性基因质菌病.
- 开始用伊特拉可纳治疗,停用Infliximab,并重新开始服用梅萨拉胺,导致症状改善.
结论:
- 传播性基因质瘤可以在接受抗TNF治疗的IBD患者中呈现异常,模仿疾病爆发或并发症.
- 对潜在暴露和非典型表现的认识对于早期诊断和干预至关重要.
- 迅速停止免疫抑制和启动抗真菌疗法对于治疗IBD患者的DH至关重要.
相关概念视频
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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
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01:28Peptic Ulcer Disease II: Pathophysiology
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01:26Peptic Ulcer Disease IV: Management
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01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
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01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
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