Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry.

Circulation·2026
Same author

Plasma proteomics improves thrombosis prediction in patients with cancer and identifies targetable IL-17-driven endothelial activation.

Science translational medicine·2026
Same author

Colocalization of eQTLs With Type 2 Diabetes and Glycemic Traits Using Whole-Genome Sequences in Diverse Populations From the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program.

Diabetes·2026
Same author

Multimodal Artificial Intelligence for Cardiac Amyloidosis Diagnosis: Integrating Echocardiography With Clinical and Laboratory Data for Improved Detection.

Circulation. Cardiovascular imaging·2026
Same author

Cardiovascular Adverse Events During Venetoclax-Based Treatment in Acute Myeloid Leukemia.

Journal of the American Heart Association·2026
Same author

Rapid Remodeling of Human White Adipose Tissue Following Bariatric Surgery.

bioRxiv : the preprint server for biology·2026
Same journal

SBK2 Links Cardiac Stress Signaling to Mitochondrial Proteostasis.

Circulation research·2026
Same journal

Myeloid Piezo1 as a Brake on Efferocytosis and Cardiac Repair in the Infarcted Heart.

Circulation research·2026
Same journal

Targeting Late Na<sup>+</sup> Current: Too Late or Better Late Than Never?

Circulation research·2026
Same journal

HFpEF-Any: Human Single-Nuclear Transcriptomics Challenging the Translational Validity of Current HFpEF Models.

Circulation research·2026
Same journal

Myovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

Circulation research·2026
Same journal

Meet the First Authors.

Circulation research·2026
查看所有相关文章

相关实验视频

Updated: Jul 23, 2025

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
13:42

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

Published on: July 17, 2012

29.0K

棕色脂肪组织和BMP3b降低心脏缺血-再输血中的损伤.

Íngrid Martí-Pàmies1, Robrecht Thoonen1,2, Michael Morley1

  • 1Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (I.M.-P., M.M., L.G., J.T., A.C., K.M., L.L., M.S.-C.).

Circulation research
|July 18, 2023
PubMed
概括
此摘要是机器生成的。

棕色脂肪组织 (BAT) 保护心脏免受 ischemia-reperfusion (I/R) 损伤的影响. 该研究确定了BAT分泌的骨形态蛋白3b (BMP3b) 作为这种心脏保护作用的关键因素,提供了新的治疗点.

关键词:
心脏衰竭是因为心脏衰竭.鼠标 鼠标 鼠标 鼠标在心肌中,心肌.转流是指转流的意思,是指转流的意思.解蛋白1 解蛋白1 是一个解蛋白.

更多相关视频

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

6.1K
A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats
09:54

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

Published on: March 23, 2018

7.9K

相关实验视频

Last Updated: Jul 23, 2025

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
13:42

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

Published on: July 17, 2012

29.0K
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

6.1K
A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats
09:54

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

Published on: March 23, 2018

7.9K

科学领域:

  • 心脏病学 心脏病学
  • 代谢过程中的代谢.
  • 分子生物学分子生物学

背景情况:

  • 心肌梗塞 (MI) 仍然是全球心力衰竭和死亡的主要原因.
  • 缺血-再输液 (I/R) 损伤显著导致心脏损伤后MI.
  • 在心脏病发作中观察到棕色脂肪组织 (BAT) 激活,分泌的因素可能会影响心脏健康.

研究的目的:

  • 在I / R设置中调查BAT对心脏损伤的保护作用.
  • 确定由BAT分泌的特定心脏保护蛋白质.
  • 阐明BAT衍生因素在减轻I/R诱导的心肌损伤方面的治疗潜力.

主要方法:

  • 使用野生型 (WT) 和脱蛋白1 (Ucp1) 缺乏的小鼠进行I/R手术,并未使用BAT移植.
  • 采用RNA测序 (RNA-seq) 来识别由BAT分泌的潜在心脏保护因素.
  • 通过使用缺乏BMP3b的小鼠和直接BMP3b治疗来研究骨形态遗传蛋白3b (BMP3b) 的作用.

主要成果:

  • 损坏的BAT功能加剧了I / R诱导的MI大小,而BAT移植减少了它.
  • BMP3b被确定为一种BAT分泌的蛋白质,可以减轻小鼠的I/R损伤.
  • 通过SMAD1/5/8信号传导,BMP3b治疗减少了心脏病发作的大小,以及与人类心脏损伤相关的血BMP3b水平升高.

结论:

  • 最佳技术及其分泌的蛋白BMP3b在I/R损伤中起着重要的心脏保护作用.
  • 准BMP3b或SMAD1/5信号传输是减少心肌损伤的有希望的治疗策略.
  • 这项研究强调了代谢组织与心脏保护之间的新联系.