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剪切波弹性图参数增加了移植接受者的不良结果的预后价值
Tian-Yi Zhang1, Jiayi Yan1,2, Jiajia Wu1
1Department of Nephrology, Molecular Cell Lab for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Ren Ji Hospital, Uremia Diagnosis and Treatment Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Renal failure
|July 18, 2023
概括
通过剪切波弹性成像 (SWE) 测量基移植硬度的增加,预测移植接受者的结果会更差. 这种非侵入性超声技术可以改善移植后不良事件的风险分层.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 放射学 放射学是一门学科.
- 移植手术 移植手术
背景情况:
- 病理变化,如淋巴结核硬化和纤维化,可以增加移植脏硬性,与较差的结果相关.
- 超声波弹性学提供了一种非侵入性方法,以定量评估组织硬度.
研究的目的:
- 为了确定超声波弹性图的预后能力,以确定移植患者的不良结局.
主要方法:
- 剪切波弹性图 (SWE) 用于测量接受者的脏全移植硬度.
- 主要结局是复合的移植恶化,重新入院和死亡率.
- 卡普兰-梅尔曲线和考克斯回归分析被用于生存分析.
主要成果:
- 在161名患者中,随访时间平均为20.1个月,16.77%的患者达到主终点.
- 骨髓组织硬度 (平均和中位数),EGFR和血清白蛋白与单变量分析中的不良结果有关.
- 将SWE纳入基线模型显著改善了对不良结果的预测.
结论:
- 通过SWE测量骨髓组织硬度为移植接受者提供了有价值的预后信息.
- 在移植中,SWE参数可以提高风险分层和患者管理.
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