对于患有多囊性卵巢综合征的女性,不积极尝试怀孕的他类药物
Ting Xiong1, Eloise Fraison2, Eleni Kolibianaki3
1Reproductive Medicine Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The Cochrane database of systematic reviews
|July 18, 2023
概括
类他类药物对多囊卵巢综合征 (PCOS) 症状,如月经规律和丸激素水平有不确定的益处. 需要更多的研究来确认PCOS女性的疗效和安全性.
科学领域:
- 内分泌学和新陈代谢学
- 生殖医学 生殖医学
背景情况:
- 多囊性卵巢综合征 (PCOS) 与失脂症和内分泌异常有关.
- 类他类药物,主要是降脂剂,具有带有潜在代谢和内分泌益处的类效应.
- 之前的审查已经探讨了在PCOS中使用他类药物,需要进行更新的评估.
研究的目的:
- 评估在被诊断患有PCOS的妇女中使用他类药物治疗的疗效和安全性.
- 评估他类药物对月经规律,排卵,荷尔蒙水平和身体症状的影响.
- 分析在没有积极试图怀孕的PCOS妇女中使用他类药物的情况.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 在多个数据库 (Cochrane,MEDLINE,Embase等) 进行了搜索. 在2022年11月之前.
- 包括将他类药物 (单独或组合) 与安慰剂,无治疗或其他药物进行比较的RCT.
主要成果:
- 包括6项涉及396名患有PCOS的妇女的RCT.
- 关于他类药物对月经的规律性,丸激素水平,疹和的影响的证据确定性非常低.
- 在对照中,他类药物和对照组之间报告的不良事件没有显著差异.
结论:
- 目前的证据基础不足以确定他类药物在改善PCOS妇女的月经规律,荷尔蒙平衡或身体症状方面的疗效.
- 由于证据的确定性非常低,这群人群中他类药物治疗的益处和风险仍然不确定.
- 需要进一步进行高质量的随机对照试验,以确定他类药物在PCOS管理中的作用.
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
702
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
702
Infertility in Females
349
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
349
Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
Hormonal Control of the Ovarian Cycle
585
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
585
Lipids: Dietary Sources and Requirements
851
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
851
Oral Hypoglycemic Agents: Biguanides and Glitazones
236
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
236


