可持续低剂量西尔代纳菲尔和认知行为训练对接受甲治疗的男性性功能的影响 - 一项随机对照试验
Negah Tavakolifard1, Zahra Amini1
1Department of Community and Family Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Journal of addictive diseases
|July 18, 2023
概括
阿片类药物诱导的性功能障碍是一个重大问题. 低剂量西尔代纳菲尔与心理训练相结合,改善了甲治疗的男性的性功能,药物显示出更大的疗效.
科学领域:
- 药理学 药理学是指药理学的学科.
- 心理学 心理学 心理学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 吸食阿片类药物,特别是甲治疗,与男性显著的性功能障碍有关.
- 解决性功能障碍对于改善接受阿片类药物替代疗法的个体的生活质量至关重要.
研究的目的:
- 评估和比较持续低剂量西尔代纳菲尔治疗与心理训练对改善性功能在甲治疗的男性持续低剂量西尔代纳菲尔治疗的疗效.
- 评估这些干预措施对勃起功能,性自我效能和性生活质量的影响.
主要方法:
- 一项随机临床试验,涉及被诊断患有性功能障碍的甲治疗男性.
- 参与者被分配到西尔代纳菲尔 (25毫克) 组或心理训练组.
- 标准化问卷 (性生活质量-男性,性自我效率尺度-勃起,国际勃起功能指数) 在干预前后进行.
主要成果:
- 西尔德纳菲尔和心理训练都在4周后显著改善了性功能.
- 与心理训练组相比,西尔德纳菲尔组在勃起功能 (p=0.003) 和性自我有效性 (p<0.0001) 中呈现出统计学上显著的改善.
- 在两组之间的性生活质量-男性分数中没有发现显著差异 (p=0.342).
结论:
- 与心理训练相比,持续低剂量西尔代纳菲尔治疗为接受甲治疗的男性提供了更显著的勃起功能和性自我有效性的改善.
- 药物和心理治疗的干预都是有效和必要的,以解决这种患者群体的性功能障碍.
- 进一步的研究可能会探索组合疗法以获得更好的结果.
相关概念视频
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
193
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
193
Disorders of the Male Reproductive System
474
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
474
Drug Therapy
73
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
73
The Placebo Effect
6.2K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.2K
Antidepressant Drugs: MAOIs and Other Agents
275
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
275
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
159
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
159


