早期改善了头癌患者的功能结果,主要瘤检测
Sandhya Kalavacherla1, Benjamin Bernard2, Sangwoo S Kim3
1School of Medicine, University of California San Diego, La Jolla, California, U.S.A.
The Laryngoscope
|July 18, 2023
概括
在未知原发性头癌 (CUP) 中确定原发性瘤会导致更好的功能结果. 与未知初级 (UP) 患者相比,已知初级 (KP) 患者的体重减轻和吞改善较小.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
背景情况:
- 不知原发性头癌 (CUP) 是一个诊断挑战.
- 功能性结果和生活质量对于管理CUP患者至关重要.
- 初级瘤识别可能会影响治疗策略和随后的结果.
研究的目的:
- 根据是否确定了主要瘤部位,对患有CUP的患者的功能结果进行表征和比较.
- 评估初级瘤识别对体重,心理困扰和吞功能的影响.
主要方法:
- 对67名CUP患者的回顾性研究,分为已知初级 (KP) 和未知初级 (UP).
- 收集的数据包括人口统计,HPV状态,诊断方法和治疗方案.
- 在UP和KP组之间比较治疗前和治疗后 (3-6个月) 的体重,PHQ-9 (抑郁症),EAT-10 (吞) 和VHI-10 (语音) 评分.
主要成果:
- 在67名CUP患者中,有35人 (52.2%) 确诊了初级病,主要是口腔喉和鼻喉.
- KP患者更年轻,更有可能是HPV阳性.
- 治疗后,与KP患者相比,UP患者的体重减轻显著增加,EAT-10得分更高 (表明吞功能障碍),PHQ-9得分更高 (表明抑郁症).
结论:
- 在CUP患者中确定原发性瘤与更好的功能结果有关,包括更少的体重减轻和减少吞困难.
- 在已知的初级 (KP) 患者中,这些好处可能归因于辐射治疗量减少,特别是喉肌肉.
- 在头癌中早期发现原发性瘤可以改善治疗后的生活质量.
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