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Updated: Jul 23, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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过氧化可诱导的PROTAC用于癌细胞中向蛋白质降解

Dehao Yu1, Heli Fan1, Zhili Zhou2

  • 1Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, The Province and Ministry Co-sponsored Collaborative Innovation Center, for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070, China.

Chembiochem : a European journal of chemical biology
|July 18, 2023
PubMed
概括

新的蛋白质溶解向化马体 (PROTACs) 在癌细胞中被过氧化 (H2O2) 激活. 这种针对性蛋白质降解策略提高了选择性,并减少了正常细胞中的毒性.

关键词:
这就是BRD4D.具有H2O2诱导性的这就是PROTAC.这是一种抗瘤药物.蛋白质降解 蛋白质降解

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