雌激素受体低阳性乳腺癌:与预后的关联
Anette H Skjervold1, Marit Valla2,3, Anna M Bofin2
1Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. anette.skjervold@ntnu.no.
Breast cancer research and treatment
|July 18, 2023
概括
雌激素受体 (ER) 低 1995年以后诊断的阳性乳腺癌 (BC) 显示尺寸较小,等级较低,扩散率较低. 这些ER低阳性BC的预后与ER高阳性瘤的预后相似,与之前诊断的不同.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 雌激素受体 (ER) 状态是乳腺癌 (BC) 分类和治疗的关键决定因素.
- 低阳性BC (ER表达≥1%和<10%) 代表了一个独特的子组,理解正在不断发展.
研究的目的:
- 调查ER低阳性BC和瘤特征之间的关联.
- 评估ER低阳性BC的预后影响与ER表达水平和诊断时代的关系.
主要方法:
- 对三大BC患者队列的分析,按诊断时代分层 (1995年之前与1995年以后),以反映辅助治疗的可用性.
- 将ER状态分类为<1%,≥1%至<10%,以及≥10%.
- 使用统计测试和生存分析,ER状态与基因病学等级,增殖,分子亚型和预后的相关性.
主要成果:
- 低ER阳性瘤 (1955年的3.3%) 在光线B (HER2+) 和3级亚型中最常见.
- 与ER阴性BC相比,ER低阳性BC的死亡风险较低.
- 从1995年开始诊断的瘤呈现出更高比例的ER低阳性BCs,具有更小的尺寸,更低的等级和更低的增殖率.
结论:
- 1995年 (辅助疗法时代) 后被诊断为ER低阳性BC的妇女呈现出有利特征的瘤 (尺寸较小,等级较低,增殖率较低).
- 在辅助治疗时代诊断的ER低阳性BC与ER高阳性瘤的预后相似,与早期诊断形成鲜明对比.
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