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2型糖尿病和肥胖对脂肪介质干细胞/干细胞免疫调节的影响

Marwa Mahmoud^1,2, Mazen Abdel-Rasheed^3,4

¹Stem Cell Research Group, Medical Research Centre of Excellence, National Research Centre, 33 El Buhouth St, Ad Doqi, Dokki, 12622, Cairo Governorate, Egypt. Marwa_aromatic_85@yahoo.com.

Cell and tissue research

|July 18, 2023

概括

脂肪基衍生干细胞 (ASC) 通过调节免疫反应,显示出治疗2型糖尿病 (T2D) 的前景. 然而,患者的肥胖和T2D严重程度等因素可能会影响它们的有效性,需要预先调节策略.

科学领域:

免疫学免疫学免疫学
代谢性疾病研究研究.
干细胞疗法是一种干细胞疗法.

背景情况:

2型糖尿病 (T2D) 涉及代谢性炎症和胰岛素抵抗,通常与肥胖有关.
脂肪酸衍生干细胞 (ASC) 是具有免疫调节和抗炎性能的中酶体干细胞.
ASCs为T2D等炎症状况提供了潜在的治疗益处,自主使用是安全的首选.

研究的目的:

审查人类ASC (hASC) 免疫调节机制,特别是关于T淋巴细胞.
探索hASCs在T2D治疗中的影响.
评估T2D和肥胖对hASC免疫调节潜力的影响.

主要方法:

关于hASC免疫调节的文献综述.
分析hASC与先天性和适应性免疫细胞通过细胞接触和膜介质的相互作用.
检查使用高脂肪饮食 (HFD) 诱导的T2D模型的临床前研究.

主要成果:

hASCs通过直接接触和分泌因子调节免疫细胞的增殖,激活和功能.
临床前研究表明,hASCs可以改善T2D模型中的炎症和代谢标志物.
关于T2D/肥胖患者的ASC功能数据是相互矛盾的,显示完整或受损的免疫调节能力.

结论:

hASCs具有与T2D治疗相关的显著免疫调节潜力.
患有T2D和肥胖症的患者特定因素可能会影响hASC的治疗疗效.
目前正在探索预条件化策略,以增强T2D治疗的hASC功能.

关键词:

肥胖的是一种脂肪.免疫调节免疫调节介质细胞体 (Mesenchymal) 是一个介质细胞体.肥胖问题肥胖问题预先条件的形成 2 型糖尿病 2 型糖尿病

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