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骨关节炎的经济和人文负担:大型样本研究的更新系统审查

Xuejing Jin¹, Wanxian Liang¹, Lining Zhang¹

¹Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, China.

PharmacoEconomics

|July 18, 2023

概括

骨关节炎 (OA) 继续给全球患者带来重大的经济和人文负担. 自2016年以来,与OA相关的直接成本已经扩大,患者与健康相关的生活质量 (HRQL) 仍然很差.

科学领域:

类风湿病学类风湿病学
卫生经济学卫生经济学
公共卫生公共卫生

背景情况:

骨关节炎 (OA) 带来了巨大的经济和人文负担.
之前的审查强调了OA对患者的重大影响.
需要进行更新的审查,以反映最近有关OA负担的数据.

研究的目的:

系统审查和更新骨关节炎 (OA) 的经济和人文负担.
分析自2016年以来发表的大型样本研究的数据.
提供当前的洞察力,了解OA的多方面的负担.

主要方法:

在Medline和Embase的系统文献搜索.
包括样本大小≥1000的研究,测量OA成本或与健康有关的生活质量 (HRQL).
两名研究人员与仲裁员进行独立审查,以查找差异;成本转换为2021美元.

主要成果:

包括54项研究,具有很高的审稿人一致性 (Kappa=0.71).
每年直接的OA成本在326美元 (日本) 到19,530美元 (美国) 之间;间接成本在736美元 (美国) 到18884美元 (荷兰) 之间.
与健康相关的生活质量 (HRQL) 仍然很差,EQ-5D和WOMAC是常见的衡量标准.

结论:

自2016年以来,OA的经济负担显示出更广泛的成本范围.
与OA相关的患者健康相关生活质量 (HRQL) 仍然很差.
需要注意的是,国际注册数据库中的OA负担数据越来越多地公布.

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