对扩大双酸盐使用的基于人口的注册研究:在关于更短治疗持续时间的里程碑性出版物之后,最小的转变
Gregory A Kline1, Suzanne N Morin2, Lisa M Lix3
1Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
概括
尽管有证据表明更短的双酸盐使用,但许多妇女继续治疗超过5或10年. 这项研究发现,大约三分之一的坚持患者仍然接受长期双酸盐治疗.
科学领域:
- 骨质疏松症的管理
- 药物监督 药物监督 药物监督
- 骨健康研究 骨健康研究
背景情况:
- 双酸盐治疗的持续时间一直在争论中,直到2006年和2008年的里程碑式研究突出了最佳治疗长度和长期使用的风险.
- 人们对长期使用双酸盐与非典型的股骨骨折之间的联系表示担忧.
研究的目的:
- 调查基准双酸盐研究是否影响了2010年以后长期治疗 (>5或>10年) 的处方模式.
- 量化接受延长双酸盐治疗的妇女的百分比.
主要方法:
- 利用马尼托巴骨矿物密度注册表与50岁以上妇女的省级药房数据联系在一起.
- 分析了从1995年至2018年的数据,重点关注口服双酸盐使用者,其坚持高 (>75%在第一年).
- 在2010年之前和之后开始治疗的妇女之间比较治疗持续时间.
主要成果:
- 64.9%的妇女接受了连续的口服双酸盐治疗超过5年,41.9%接受了超过10年.
- 虽然5年完成率在后期略有下降 (74.4%对70.2%),但超过10年的治疗减少更为明显 (46.6%对33.5%).
- 药物持有率仍然很高,每年超过79%.
结论:
- 具有里程碑意义的研究可能已经适度地减少了双酸盐治疗的持续时间.
- 很大一部分坚持治疗的患者,高达三分之一,即使在现代时代,也继续接受双酸盐治疗超过10年.
- 需要进一步的研究来平衡扩大双酸盐使用的好处和风险.
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