针对呼吸道病毒的mRNA疫苗
Jennifer A Whitaker1,2, Hana M El Sahly1,2, C Mary Healy3
1Department of Molecular Virology and Microbiology.
Current opinion in infectious diseases
|July 18, 2023
概括
针对COVID-19的信使RNA (mRNA) 疫苗刺激了针对其他呼吸道病毒的新mRNA疫苗的快速开发. 这些先进的疫苗在针对流感,RSV和其他病原体的临床试验中表现有前途.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 分子生物学分子生物学
- 传染性疾病 传染性疾病
背景情况:
- 针对COVID-19的mRNA疫苗的成功催化了对其他呼吸道病毒类似平台的研究.
- mRNA疫苗技术为开发针对新兴和季节性呼吸道病原体的疫苗提供了快速和可适应的方法.
研究的目的:
- 审查由COVID-19疫苗成功推动的mRNA疫苗技术的进步.
- 为各种呼吸道病原体提供mRNA疫苗开发进展的最新信息.
主要方法:
- 关于mRNA疫苗的最新临床试验数据和科学文献的审查.
- 针对流感,呼吸道同胞病毒 (RSV) 和其他呼吸道病毒的候选疫苗的分析.
主要成果:
- COVID-19 mRNA疫苗在预防严重疾病和死亡方面已被证明是有效的.
- 针对禽流感 (H7N9,H10N8),季节性流感,RSV,人类甲型肺病毒和类型3的mRNA疫苗正在临床试验的各个阶段 (1-3期).
- 针对多种呼吸道病毒的组合mRNA疫苗也在研究中.
结论:
- 对呼吸道病毒的mRNA疫苗开发正在迅速进展.
- 有前途的mRNA疫苗候选人正在通过临床试验来评估对呼吸道病毒疾病的疗效.
更多相关视频
相关概念视频
Pneumonia V: Nursing management and Prevention
2.2K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.2K
Vaccinations
44.8K
Overview
44.8K
Microorganisms in Medicine and Therapeutics
62
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
62
Common Respiratory Disorders
698
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
698
Viruses with RNA Genomes
57
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
57
Drugs Used in Upper Respiratory Disorders: Overview
292
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
292


