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Updated: Jul 23, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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通过协奏组 [4 + 2] - 循环添加/芳香反应构建取消的Spiro[4.4]-nonane-diones

Konstantin S Ivanov1, Denis E Samburskiy1, Leila V Zargarova1,2

  • 1Laboratory of Low-carbon Chemical Technologies, ORËL Research Lab, Novosibirsk State University, Novosibirsk 630090, Russia.

The Journal of organic chemistry
|July 18, 2023
PubMed
概括

一种新的迪尔斯-阿尔德反应方法合成了合的spiro[4.4]-nonane-dione衍生物. 这种高效的过程涉及螺旋基和活性基,使得可以产生对称和不对称的化合物.

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The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
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