[精子血弹性酶与精子反应性氧物种和不孕男性精液参数的相关性]
Jin-de Zhu1, Yi Yu2, Yu Li1
1Department of Urology, Nanjing School of Clinical Medicine, Southern Medical University / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.
Zhonghua nan ke xue = National journal of andrology
|July 18, 2023
概括
精子血弹性酶 (SPE) 水平与精子白细胞,精子反应性氧物种 (ROS) 和不孕男性的DNA碎片化相关. 升高的SPE表明炎症和潜在的不孕症标志物.
科学领域:
- 生殖生物学 生殖生物学
- 安德罗学与人类学
- 生物化学 生物化学
背景情况:
- 男性不孕症是一个重大的健康问题.
- 精液等离子弹性酶 (SPE) 是一种酶,在男性生殖健康方面具有潜在作用.
- 了解与不孕症相关的标志物对于诊断和治疗至关重要.
研究的目的:
- 调查精液等离子弹性酶 (SPE) 和精子反应性氧物种 (ROS) 之间的关系.
- 检查SPE与不育男性的各种精液参数的关联.
- 为了确定SPE在男性不孕症的诊断价值.
主要方法:
- 在2021年7月至12月期间,有145名不育男性被录取.
- 测量包括SPE,精液白细胞,精子ROS,DNA碎片化指数 (DFI) 和标准精液参数.
- 患者被分为炎症 (SPE ≥290 ng/ml) 和非炎症组.
主要成果:
- 与非炎症组相比,炎症组的精子白细胞,精子ROS和DFI显著增加 (P <0.05).
- SPE与精子白细胞 (r = 0.658),精子ROS (r = 0.229) 和DFI (r = 0.192) 正相关.
- 两组之间在精液量,精子度,运动性或形态学方面没有发现显著差异.
结论:
- 精液等离子弹性酶水平与精液白细胞,精子ROS和DFI相关.
- 在诊断男性不孕症方面,SPE显示出作为参考标记物的潜力.
- 这些发现强调了SPE在炎症相关的男性不孕症中的作用.
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