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肺修复和再生的循环节调节
Amruta Naik1, Kaitlyn M Forrest1, Oindrila Paul1
1Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
JCI insight
|July 18, 2023
概括
扰乱昼夜节律与病毒感染后更糟糕的结果和受损的肺部修复有关. 了解人体时钟的理解
科学领域:
- * 肺部医学 肺部医学
- * * 时间生物学
- * 传染病 传染病
背景情况:
- *最佳的肺修复对于从流感A病毒 (IAV) 等病毒感染中恢复至关重要.
- *以前的研究表明,昼夜控制对急性IAV诱导的炎症和死亡率.
- * 昼夜节律对感染后肺部健康的长期影响尚不清楚.
研究的目的:
- * 调查昼夜节律扰乱与下呼吸道感染 (LRTI) 发病率之间的关联.
- * 探索昼夜时钟在IAV感染后的肺修复和再生中的作用.
- * 确定肺再生中受到昼夜时钟影响的特定分子通路.
主要方法:
- *对英国生物库数据的分析,以将昼夜节律与LRTI结果相关联.
- *使用肺器官来评估昼夜时钟功能的体外研究.
- * 单细胞RNA测序和IAV感染模型,具有被破坏的昼夜时钟.
主要成果:
- * 较差的昼夜节律与增加LRTI发病率,住院和死亡率有关,即使调整了混因素.
- * 肺部有机体具有功能性的昼夜时钟,其中断会损害再生能力.
- * 昼夜时钟通过气管细胞中的Wnt/β-catenin通路和膜上皮细胞中的IL-1β调节肺再生.
结论:
- *循环节律障碍会对肺部健康和病毒感染后的修复产生负面影响.
- * 昼夜时钟在肺的再生过程中起着至关重要的作用.
- * 准昼夜通路可能为改善肺部修复和患者结果提供新的治疗策略.
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