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相关概念视频

Solvents01:12

Solvents

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A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
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Titration in Nonaqueous Solvents01:16

Titration in Nonaqueous Solvents

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Most acid-base titrations are performed in an aqueous medium. In aqueous titrations, water competes with weaker acids or bases for proton donation or acceptance, leading to ambiguous endpoints in the titration curve. Water also affects the partial ionization of weak acids or bases. For example, water accepts a proton from acetic acid to form hydronium and acetate ions. The hydronium ion formed is a stronger acid than acetic acid, and the acetate ion is a stronger base than water. As a result,...
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相关实验视频

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深度修复性溶剂:一种环保的设计,用于制药工程.

Feras Oyoun1,2, Antoniya Toncheva2, Luis Castillo Henríquez1

  • 1CNRS, Inserm, Chemical and Biological Techniques for Health (UTCBS), Université Paris Cité, School of Pharmacy, 4 avenue de l'Observatoire, F-75006, Paris, France.

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概括

深度浸泡溶剂 (DES) 为药房中的传统有机溶剂提供了一个可持续的,更绿色的替代品. 这些多功能化合物显示出开发具有有益环境和物理化学性质的新型治疗性DES (TheDES) 的前景.

关键词:
药物输送系统是药物输送系统.药物设计 药物设计绿色化学是一种绿色化学.聚合物是一种聚合物.治疗性深层感溶剂 治疗性深层感溶剂

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科学领域:

  • 绿色化学 绿色化学
  • 可持续的药房 可持续的药房
  • 材料科学 材料科学 材料科学

背景情况:

  • 有机溶剂由于环境和健康问题而面临限制.
  • 深度环氧溶剂 (DES) 正在成为具有有利性质的环保替代品.
  • 德斯具有低成本,生物相容性和有效溶解活性药物成分 (API) 等优势.

研究的目的:

  • 提供DES的全面概述,包括其定义,分类,准备和表征.
  • 引入天然来源中发现的天然DES (NaDES).
  • 介绍选择DES成分的新策略,以优化实验效率,并讨论它们的制药应用.

主要方法:

  • 文献综述和对DESs现有研究的综合.
  • 详细的DES和NaDES的分类和特征.
  • 探索选择DES组件的方法及其在药物输送中的作用.

主要成果:

  • 定义和分类了DES,并概述了它们的制备和表征方法.
  • 描述了自然DES (NaDES),强调了它们的起源和特性.
  • 该审查详细介绍了选择DES成分的方法,并讨论了它们在制药和生物医学应用中的潜力,包括治疗性DES (TheDES).

结论:

  • DESs代表了药物应用可持续化学的重大进步.
  • 谨慎选择DES组件可以简化新疗法的开发.
  • 对于绿色药房的未来和有效治疗剂的创造,DES具有相当大的前景.