围产期铁限制与新生儿心脏功能和结构的变化有关,这种变化取决于性别
Ronan M N Noble1,2, Claudia D Holody1,2, Andrew G Woodman3
1Department of Pediatrics, University of Alberta, Edmonton, Canada.
Clinical science (London, England : 1979)
|July 18, 2023
概括
怀孕大鼠缺铁会影响后代的心脏发育,导致雄性和雌性分别出现明显的静缩和静缩功能障碍. 这些发现突显了新生儿心脏健康的关键风险.
科学领域:
- 发展生物学 发展生物学
- 心血管生理学心血管生理学
- 营养科学 营养科学
背景情况:
- 铁缺乏症 (ID) 和贫血在怀孕和婴儿期普遍存在,可能会影响长期的心血管健康.
- 对于围产期缺铁对新生儿心脏发育和功能的具体影响的了解有限.
研究的目的:
- 调查母亲铁缺乏对新生儿期后代心脏发育和功能的影响.
- 在子宫内暴露于铁缺乏症的新生儿中识别特定性别的心脏功能障碍和潜在的分子机制.
主要方法:
- 在妊娠前和妊娠期间,雌性Sprague-Dawley大鼠接受了铁限制或铁补充饮食.
- 在4日,14日和28日使用心声学评估后代的心脏功能.
- 量化射击炮蛋白质组学是在一个单独的后代队伍的心脏组织上进行的.
主要成果:
- 在所有评估时间点上,缺铁导致后代体重减轻,心脏体重相对增加.
- 心声扫描揭示了性别特异性心脏功能障碍:男性表现出更大的心性损伤,而女性表现出更大的心性损伤.
- 蛋白质组分析表明结构蛋白的下调和丰富的细胞应激反应在缺铁后代,在男性更明显的影响.
结论:
- 周产期缺铁会诱导新生儿的功能性心脏变化,可能代表对贫血的不适应性补偿.
- 缩和透缩功能障碍被确定为围产期缺铁性贫血的并发症,对新生儿的心脏健康有影响.
- 旨在改善心脏输出的治疗策略可能提供一种手段,以减轻缺铁对新生儿器官发育的不良影响.
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