在NAFLD和血清尿酸与血清肌素比率之间的相关性
Jangwon Choi1, Hyun Joe1, Jung-Eun Oh2
1Department of Family Medicine, College of Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.
PloS one
|July 18, 2023
概括
血清尿酸/肌素 (sUA/sCr) 比率与韩国成年人非酒精性脂肪肝 (NAFLD) 严重程度相关. 较高的sUA/sCr水平表明脂肪肝疾病的严重程度增加,表明其作为诊断标记物的潜力.
科学领域:
- 肝病学和胃肠道学
- 生物标志物和诊断方法
- 公共卫生和流行病学
背景情况:
- 全球非酒精性脂肪性肝病 (NAFLD) 的流行率不断上升,需要改进非侵入性诊断方法.
- 血清尿酸/肌素 (sUA/sCr) 比率已经成为脂肪肝疾病的潜在指标.
- 这项研究调查了韩国成年人群中sUA/sCr水平和诊断的NAFLD之间的关联.
研究的目的:
- 检查血清尿酸/肌素 (sUA/sCr) 比率与超声波诊断的非酒精性脂肪性肝病 (NAFLD) 之间的关系.
- 评估sUA/sCr水平与NAFLD严重程度的相关性.
- 为了评估NAFLD的sUA/sCr比率的诊断性能.
主要方法:
- 对11791名韩国成年人 (≥20岁) 进行健康检查的分析,不包括特定条件和数据限制.
- 使用后勤回归分析计算了关于NAFLD存在和严重程度的sUA/sCr比率的几率比率 (OR) 和95%置信区间 (CI),并对混变量进行了调整.
- 使用接收器操作特征 (ROC) 曲线分析来确定sUA/sCr比率的灵敏度和特异性,以检测NAFLD.
主要成果:
- sUA/sCr比率显示出与NAFLD严重程度有显著的积极关联.
- 调整后NAFLD的几率比为1.183 (95% CI: 1.137-1.231),随着严重程度的增加,轻度病例为1.147 (95% CI: 1.099-1.196),中度至重度病例为1.275 (95% CI: 1.212-1.341).
- 对于脂肪肝严重性的sUA/sCr的灵敏度和特异性在56.7%至65.2%之间,根据疾病阶段而有所不同.
结论:
- 血清尿酸/肌素 (sUA/sCr) 比率与非酒精性脂肪肝疾病 (NAFLD) 的严重程度有显著联系.
- sUA/sCr比率显示出作为评估NAFLD严重程度的非侵入性生物标志物的潜力.
- 需要进一步的研究来验证sUA/sCr比率在NAFLD诊断和管理中的临床实用性.
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