多代逆境对人类肠道微生物组合和早期儿童社会情感功能产生影响
Francesca R Querdasi1, Craig Enders1, Neerja Karnani2
1Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095.
概括
代际逆境影响儿童的肠道微生物群,可能影响心理健康. 这项研究将母亲虐待和焦虑与儿童的肠道细菌变化联系在一起,这表明针对代际心理健康风险的微生物向干预措施.
科学领域:
- 精神病学是一个精神病学.
- 微生物学 微生物学
- 发展心理学 发展心理学
背景情况:
- 产前和产后的逆境增加了心理病理的风险,在几代人中延续.
- 肠道微生物组是代际风险传播的潜在生物机制.
- 动物模型表明,早期生活压力和肠道微生物组变化之间存在联系.
研究的目的:
- 检查多代逆境暴露与幼儿肠道微生物组合之间的关联.
- 调查母亲童年虐待,产前焦虑和孩子的压力生活事件对肠道微生物群的影响.
- 探索肠道微生物组功能与儿童社会情绪功能之间的关系.
主要方法:
- 在新加坡对450个母婴双进行横截面研究.
- 在2岁的第二代儿童中分析肠道微生物组的组成.
- 在两代人之间评估了三种不同的逆境暴露.
主要成果:
- 截然不同的肠道微生物组形状与每种类型的逆境暴露有关.
- 一些与逆境相关的微生物种群与与儿童社会情感功能相关的共享功能.
- 特定的微生物组特征,如β多样性,并没有被逆境持续影响.
结论:
- 逆境的代际传播可能会通过改变肠道微生物组功能影响儿童的心理健康.
- 肠道微生物组是旨在减轻跨代心理健康风险的干预措施的潜在目标.
- 这些发现为跨代逆境传播和心理健康的机制开辟了新的研究途径.
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