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低素诱导膀衰老的迹象与排泄功能障碍和下泌尿道重塑
Lori A Birder1,2, Amanda S Wolf-Johnston1, Irina Zabbarova1
1Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
在老鼠中,慢性暴露于素 (HX) 引起了氧化应激和膀变化,模仿与年龄相关的下泌尿道综合征 (LUTS). 这表明HX-ROS损伤可能会推动LUTS的发展,为地质科学提供干预目标.
科学领域:
- 老年学是一门学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物化学 生物化学
背景情况:
- 下尿路综合征 (LUTS) 包含尿路症状,包括尿失禁,老龄化是主要的危险因素.
- 与年龄相关的LUTS的生物化学基础尚不清楚.
- 纯氨酸代谢物桑丁 (HX) 与反应性氧物种 (ROS) 生成和组织损伤有关.
研究的目的:
- 为了研究这种假设,慢性暴露于素及其相关的活性氧物种 (HX-ROS) 损害下泌尿道 (LUT) 组织.
- 为了确定HX-ROS暴露是否模仿了与年龄相关的膀变化.
主要方法:
- 成年雌性Fischer 344只大鼠在饮用水中接受了车载物或素 (HX) 治疗3周.
- 评估了纯氨酸代谢,氧化应激和细胞损伤生物标志物.
- 评估了膀结构和功能,包括囊泡测量和泄漏点压力.
主要成果:
- 暴露于HX增加了氧化应激生物标志物和减少了细胞能量 (NAD+水平).
- 在接受HX治疗的老鼠中,发生了显著的膀重塑.
- 排空功能受损,以减少交收缩间隔和较低的泄漏点压力为证.
结论:
- 在老鼠中,慢性HX暴露会引起膀变化和与衰老相似的排泄功能障碍.
- 增加的HX水平和随后的ROS相关的细胞损伤可能是与年龄相关的LUTS的关键因素.
- 这些发现表明LUTS的潜在的老年科学指导的治疗目标.
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