口服万科米可以缓解由慢性病引发的心力衰竭
Kohei Fukuoka1, Yuya Yoshida2, Kurumi Sotono2
1Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Biochemical and biophysical research communications
|July 18, 2023
概括
在慢性病 (CKD) 的小鼠中,万科米辛治疗减少了有害的肠道细菌代谢物,改善了心脏健康和生存率. 这表明,准肠道微生物群可以治疗慢性病患者的心血管问题.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 微生物学 微生物学
- 心脏病学 心脏病学
背景情况:
- 慢性病 (CKD) 破坏肠道微生物群,导致心血管炎症和纤维化.
- 在晚期功能障碍中,肠道微生物群衍生的尿素毒素对心脏有毒作用尚不清楚.
研究的目的:
- 在5/6腎切除 (5/6Nx) 的CKD小鼠模型中,研究香草素 (VCM) 對腸道微生物群和心臟病理的影響.
- 探索向肠道微生物群的潜力,以减轻CKD中的心血管并发症.
主要方法:
- 建立了一个5/6Nx小鼠模型,以诱导不可逆转的淋巴结核硬化和管间纤维化.
- 范科米辛 (VCM) 被用于评估其对肠道微生物群,尿路毒素水平和心脏病理学的影响.
- 测量包括血液中的硫酸,硫酸,大脑尿素和心脏纤维化.
主要成果:
- 施用VCM降低了血液中的氧硫酸盐和硫酸盐水平,这是关键的肠道细菌衍生的尿素性物质.
- 心脏病理标志物,包括大脑天然尿素和纤维状区域,在VCM治疗后减少.
- 在5/6Nx小鼠中,VCM阻止了体重减轻和延长生存时间.
结论:
- 范科米辛诱导肠道微生物群的调节改善了心力衰竭,并改善了晚期CKD的存活率.
- 减少肠道微生物群衍生的心脏毒性物质是CKD心血管并发症的潜在治疗策略.
- 准肠道微生物群为预防和治疗慢性病患者心血管疾病提供了一个有希望的方法.
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