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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

815
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
815

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Updated: Jul 23, 2025

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
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循环的T细胞形状与内型特征相关,是血液性恶性瘤复发的基础.

Nicolas Vallet1, Maud Salmona2, Jeanne Malet-Villemagne3

  • 1Université de Paris Cité, INSERM U976, 75010 Paris, France.

Cell host & microbe
|July 18, 2023
PubMed
概括

在干细胞移植后早期使用阿兹罗米辛可能会通过改变肠道微生物组增加癌症复发. 这项研究揭示了抗生素如何影响肠道细菌,病毒和代谢物,可能影响免疫细胞并导致复发.

关键词:
全源性造血干细胞移植 造血干细胞移植抗生素 抗生素是一种抗生素.抗瘤免疫反应 免疫反应亚齐特罗米辛是一种亚齐特罗米辛.癌症 癌症 癌症 癌症 癌症肠道病毒病毒ome血液学复发的复发这是一个代谢组的代谢组.微生物组是一个微生物组.

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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry
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科学领域:

  • 微生物组研究的研究.
  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.

背景情况:

  • 全基性造血干细胞移植 (HSCT) 是血液恶性瘤的关键治疗方法.
  • 在HSCT后早期服用阿兹罗米辛与复发风险增加有关.
  • 阿齐思罗米影响移植后结果,特别是复发的确切机制尚不清楚.

研究的目的:

  • 在HSCT后,研究阿齐思罗米对肠道生态系统的影响.
  • 探索肠道微生物组变化与癌症复发之间的关系.
  • 识别与缓解或复发相关的特定微生物和代谢特征.

主要方法:

  • 肠道细菌组,病毒组和代谢组的纵向表征在55名接受HSCT的患者中.
  • 患者接受了阿齐思罗米辛或安慰剂.
  • 对肠型,菌体物种,代谢途径和免疫细胞状态的分析.

主要成果:

  • 确定了四种不同的肠肠类型,以及相关的菌体网络和代谢途径.
  • 一种肠型与持续缓解有关.
  • 特定的细菌种群 (Bacteroides,Prevotella) 和代谢途径 (脂质,糖,分支链氨基酸) 与缓解或复发相关.
  • 肠道微生物群和代谢物的变化与耗尽的T细胞和免疫细胞功能有关.

结论:

  • 阿齐思罗米在HSCT后显著影响复杂的肠道生态系统 (细菌,病毒,代谢物).
  • 这些抗生素诱导的变化可能通过调节免疫细胞功能来促进癌症复发.
  • 准肠道微生物组可能为改善HSCT结果和预防复发提供新的策略.