通过混合加工的尼古丁 - 酸复合物:用于作为粘粘性口腔盘中的药物载体的特征
Napaphak Jaipakdee1, Thitiphorn Rongthong2, Watchara Kanjanakawinkul2
1Division of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
International journal of pharmaceutics
|July 18, 2023
概括
尼古丁 (NCT) 通过物理混合与酸 (MAS) 复合,提供持续释放. 这些NCT-MAS复合体在口腔配方中显示出作为粘粘性药物载体的潜力.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 尼古丁 (NCT) 与酸盐 (MAS) 的复合传统上需要多个制备步骤.
- 了解NCT-MAS复合物的相互作用和释放机制对于药物输送应用至关重要.
研究的目的:
- 开发一种生产NCT-MAS复合物的简化方法.
- 描述NCT-MAS复合体并评估它们在口服配方中的药物载体潜力.
主要方法:
- 使用单步物理混合方法制备NCT-MAS复合物.
- 描述涉及富里埃变换红外光谱学 (FTIR),X射线衍射 (XRD) 和29Si核磁共振 (NMR).
- 实验室释放研究在pH 6的酸盐缓冲中进行,口腔盘用藻酸盐 (SA) 配制.
主要成果:
- 物理混合成功地产生了NCT-MAS复合物,在7天的休息期内NCT插入到MAS酸盐层中.
- FTIR,XRD和29Si NMR表明通过结,水桥和离子静电力相互作用.
- 12%的NCT-MAS复合体表现出持续的NCT释放,由粒子扩散控制,以及在SA度下降的口腔盘中增强的释放/透.
结论:
- 一个简单的,单步物理混合过程可以有效地产生NCT-MAS复合体.
- NCT-MAS复合物表现出持续释放性质和粘粘性特征,使它们成为口腔矩阵配方的有希望的药物载体.
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