在分布式数据网络中的外部有效性
Michael Webster-Clark1,2, Sengwee Toh3, Jonathan Arnold4
1Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada.
Pharmacoepidemiology and drug safety
|July 18, 2023
概括
分布式网络中的外部有效性是复杂的,没有一种方法适合所有. 哨兵,CNODES和PCORnet展示了各种策略,以确保研究结果适用于不同人群和环境.
科学领域:
- 药学流行病学 药学流行病学
- 医疗保健服务研究 医疗服务研究
- 数据科学数据科学数据科学
背景情况:
- 分布式网络越来越多地用于观察性研究,但外部有效性仍未得到充分研究.
- 内部有效性往往是优先考虑的,使得分布式网络中的外部有效性挑战得到了较少的探索.
研究的目的:
- 定义与外部有效性相关的关键术语 (通用性,可传输性).
- 检查像Sentinel,CNODES和PCORnet这样的分布式网络如何处理外部有效性.
- 在这些网络中确定对外部有效性的多种方法.
主要方法:
- 定义了核心概念:外部有效性,目标人群,目标有效性,可概括性,可运输性.
- 描述了Sentinel,CNODES和PCORnet对外部有效性的方法.
- 包括案例研究来说明网络特定的策略.
主要成果:
- 哨兵专注于美国人口的代表性,解决某些群体的潜在排斥.
- 为了进行元分析,CNODES必须考虑数据在美国,加拿大和英国人口之间可传输.
- 对于实用试验和研究特定的队列,PCORnet采用个案对个案的外部有效性评估.
结论:
- 没有一种通用方法来解决分布式网络中的外部有效性.
- 为分布式网络环境调整现有的外部有效性工具至关重要.
- 药物流行病学中的比较有效性研究需要针对外部有效性的定制方法.
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