肝脏疾病中的肠道菌群变化:系统性审查
Cássio Marques Perlin1,2, Larisse Longo1,2, Melina Belén Keingeski1,2
1Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-002, Brazil.
Medical mycology
|July 18, 2023
概括
改变的肠道真菌或真菌生物群与肝脏疾病的进展有关. 虽然研究有限,但Candida物种在肝硬化患者中显著增加,这表明肝病中肠道真菌特征明显.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 菌类学 菌类学是指菌类学.
背景情况:
- 肠道真菌 (mycobiota) 显著影响健康和疾病过程.
- 肝脏疾病中的真菌感染与高死亡率有关.
- 了解肠道菌群在肝病中的作用对于患者的治疗结果至关重要.
研究的目的:
- 审查和评估有关肠道菌群和成人肝脏疾病之间的关系的现有科学证据.
- 为了确定与不同阶段和类型的肝病相关的特定真菌变化.
- 评估目前的研究状况,并确定有关肝病中人类真菌生物特征的知识差距.
主要方法:
- 在PubMed和Embase数据库的系统文献搜索.
- 纳入标准:对患有肝病的成年人 (≥18岁) 的研究,发表于2010年以后.
- 评估有关肠道菌群和肝脏疾病相关性的科学证据.
主要成果:
- 患有肝病的个体表现出与疾病进展相关的改变肠道菌生菌瘤.
- 肝硬化患者表现出Candida物种的高流行率,特别是Candida albicans.
- 早期慢性肝病显示阿尔法多样性增加 (不包括Candida),而晚期疾病与末期肝病模型 (MELD) 得分有负相关性;非酒精性脂肪肝患者的多样性比对照群更大.
结论:
- 关联肠道菌群和肝病的证据目前稀少,研究有限,报告缺乏标准化.
- 尽管有局限性,但某些真菌属,如Candida,在肝病的背景下发挥着重要作用.
- 与健康个体相比,患有肝病的成年人具有明显的肠道真菌生物特征.
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