关于系统审查COPD患者炎症标志物与肺功能,肌肉力量和运动能力之间的关联的议定书
Nadhirah Mohd Noor1, Zawani Mustaffa1,2, Alia Nizam1,3
1Centre for Physiotherapy Studies, Faculty of Health Sciences, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Malaysia.
BMJ open
|July 18, 2023
概括
本系统性综述研究了慢性阻塞性肺病 (COPD) 的成年人中炎症标志物与肺功能,肌肉强度和运动能力的关系. 它还探讨了影响这些标记物的因素,如住院和炼计划.
科学领域:
- 肺部医学 肺部医学
- 炎症研究 炎症研究
- 慢性肺炎的系统性影响
背景情况:
- 慢性阻塞性肺病 (COPD) 的患病率正在增加,恶化导致严重负担.
- 患有COPD的患者表现出异常的全身炎症.
- 现有研究表明,炎症标志物与运动能力和肌肉力量等临床结果之间存在负相关性.
研究的目的:
- 系统地审查COPD患者的炎症标志物与肺功能,肌肉力量和运动能力之间的关联的证据.
- 研究诸如住院和运动计划等因素对COPD炎症标志物水平的影响.
主要方法:
- 将对Scopus,PubMed,Cochrane,Web of Science和ProQuest数据库进行全面的搜索. 将进行一个全面的搜索.
- 数据提取和资格选将由四名独立审查员进行.
- 方法质量将使用Cochrane偏差风险或纽卡斯尔-太华尺度进行评估,并使用随机效应模型计算聚合效应大小.
主要成果:
- 本节不适用于协议.
结论:
- 本系统审查协议概述了一种严格的方法来综合目前关于COPD炎症标志物的证据.
- 研究结果将阐明炎症与关键临床结果之间的关系,为潜在的治疗目标和管理策略提供信息.
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