巨大的蛋白尿和小的妊娠年龄在子宫前的低蛋白质血与巨大的蛋白尿之间的关联:一个单中心,回顾性队列研究使用倾向性得分匹配
Yanxiang Lv1, Ying Zhou1, Rui Hu1
1Obstetrics and Gynecology Intensive Care Unit, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, China.
BMJ open
|July 18, 2023
概括
患有先兆子的女性经历过低蛋白质血 (低蛋白质) 和大量蛋白质尿 (尿液中的高蛋白质) 患有更高的婴儿发病率. 这种情况也与胎儿生长问题相关.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 孕前是一种严重的妊娠并发症,其特点是高血压和其他器官系统受损的迹象.
- 低蛋白质血症和大量蛋白尿是疾病严重程度的潜在指标,可能会影响胎儿的结果.
研究的目的:
- 调查低蛋白质血与大量蛋白尿之间的关联,以及妊娠年龄小 (SGA) 婴儿在妊娠前的发病率.
- 为了确定潜在的风险因素,为不良的胎儿结果在先性怀孕.
主要方法:
- 这是一项回顾性队列研究,包括468名被诊断患有先兆子的患者.
- 倾向性得分匹配用于将大量蛋白尿症 (> 3.5 g/天) 与低血清白蛋白 (< 30 g/L) 组与对照组进行比较.
- 主要结局是SGA婴儿的发病率;次要结局包括胎儿死亡,NICU入院和孕产妇并发症.
主要成果:
- 大量蛋白尿症组的SGA发病率 (33.76%对20.51%),严重SGA发病率 (14.70%对7.69%) 和胎儿生长限制率 (23.93%对16.24%) 显著更高.
- 大量蛋白尿症组的婴儿也有更高的新生儿重症监护室入院率 (67.52%对58.55%) 和较低的出生体重中位数.
- 大多数母亲的结局没有发现显著差异,尽管巨大的蛋白尿症组的脏参数更差.
结论:
- 低蛋白质血症与大量蛋白尿结合,显着与胎儿生长限制和妊娠年龄较小的婴儿在子宫前的发病率增加有关.
- 这些发现强调了监测前症患者的蛋白质水平的重要性,以确定患有生长不良和不良结果风险的胎儿.
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