尼古丁胺胺单核酸 (NMN) 脱胺化中的宿主微生物群相互作用
Lynn-Jee Kim1, Timothy J Chalmers1, Romanthi Madawala1
1School of Biomedical Sciences, UNSW Sydney, NSW, Australia.
FEBS letters
|July 18, 2023
概括
尼古丁胺胺单核酸 (NMN) 可以通过哺乳动物的新途径进行处理,独立于肠道微生物组. 肠道微生物组与宿主竞争NMN,影响NAD+代谢.
科学领域:
- 生物化学 生物化学
- 微生物学 微生物学
- 衰老研究研究 衰老研究
背景情况:
- 尼古丁胺胺氨基二核酸 (NAD+) 对细胞过程至关重要,并且随着年龄的增长而下降.
- 尼古丁胺胺单核酸 (NMN) 是一种NAD+前体,研究了与年龄相关的疾病.
- 肠道微生物在NMN代谢中的作用基本上是未知的.
研究的目的:
- 为了研究口服NMN的代谢命运.
- 确定肠道微生物群对NMN生物可用性和NAD+代谢的影响.
- 探索NMN被纳入NAD+的其他途径.
主要方法:
- 通过口服给动物的NMN.
- 用抗生素治疗以耗尽肠道微生物群.
- 在宿主组织中分析NAD+代谢产物.
- 追踪NMN结合路径. 追踪NMN结合路径. 追踪NMN结合路径.
主要成果:
- 口服的NMN可以通过哺乳动物组织的de novo途径去amid化并纳入NAD +.
- 在由于抗生素治疗而缺乏肠道微生物群的动物中,这种途径的活性降低了.
- 抗生素治疗增加了NAD+代谢物的宿主可用性,这表明微生物组竞争.
- 肠道微生物组可能与宿主竞争食用NAD+前体.
结论:
- 口服NMN代谢涉及宿主新生合成,受肠道微生物群的影响.
- 肠道微生物组在调节NAD+前体可用性方面发挥着作用.
- 对于衰老研究来说,NMN,肠道微生物组和宿主NAD+代谢之间的相互作用是重要的.
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