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对双相情感障碍的药物治疗模式:一项GBC调查
Balwinder Singh1, Anastasia K Yocum2, Rebecca Strawbridge3
1Mayo Clinic, Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Bipolar disorders
|July 18, 2023
概括
这项关于双相情绪障碍 (BD) 药物治疗的研究发现情绪稳定剂,抗精神病药物和抗抑郁药物是常见的,但的使用量因地区而异. 处方模式可能与指导方针不一致,强调需要基于证据的治疗改进.
科学领域:
- 精神病学和制药科学 精神病学和制药科学
- 全球心理健康研究研究
- 临床药理学 临床药理学
背景情况:
- 双极性障碍 (BD) 的治疗需要了解当前的药物治疗实践.
- 全球BD治疗模式的变化需要在不同人群中进行调查.
研究的目的:
- 调查北美,欧洲和澳大利亚的双相情感障碍 (BD) 的药物治疗模式.
- 为了识别BD患者处方药物的区域差异.
主要方法:
- 利用了来自全球双极性队列网络的数据,包括10,351名个人.
- 通过通用线性混合方法进行聚合的比例元分析来分析处方模式.
- 收集了关于药物治疗,人口统计,诊断亚型和并发症的数据.
主要成果:
- 最常被处方的是稳定情绪的抗药 (44%),第二代抗精神病药 (42%) 和抗抑郁药 (38%).
- 的处方不同:澳大利亚31%,欧洲36%,整体29%.
- 第一代抗精神病药在欧洲 (24%) 比北美 (1%) 更常见. 在BD-II中,抗抑郁药的使用率高于BD-I (35%),而不是BD-II (47%).
结论:
- 对双相情感障碍 (BD) 的处方模式可能不总是遵循指南.
- 在BD药物治疗中存在显著的地理差异,包括北美的低利用率和欧洲第一代抗精神病药物的更高使用率.
- 需要进行长度研究来探索这些差异,并为基于证据的BD治疗指南提供信息.
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