人类饮食中的营养冗余及其在表型关联研究中的应用
Xu-Wen Wang1, Yang Hu2, Giulia Menichetti1,3
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Nature communications
|July 18, 2023
概括
人类的食物摄入量有所不同,但由于营养冗余,营养摄入量是稳定的. 这种稳定性预测健康的衰老和心血管疾病和2型糖尿病的风险较低.
科学领域:
- 营养科学 营养科学
- 人类健康 人类健康 人类健康
- 慢性疾病流行病学 慢性疾病流行病学
背景情况:
- 了解人类的饮食摄入量对于管理营养影响的慢性疾病至关重要.
- 之前的研究往往集中在食物摄入量上,食物摄入量可能是高度可变的.
- 稳定的营养摄入模式可能提供更一致的健康预测指标.
研究的目的:
- 调查营养摄入资料的稳定性,尽管食物消费的变化.
- 引入和量化"营养多余"的概念.
- 评估营养冗余与健康衰老和慢性疾病风险的关联.
主要方法:
- 分析了来自不同时间尺度的五个队伍的饮食摄入数据.
- 检查食品营养网络结构.
- 对个体饮食评估的营养冗余的量化.
- 营养冗余与传统健康饮食得分的比较.
- 统计分析与健康老龄化,心血管疾病和2型糖尿病风险的关联,根据年龄进行调整.
主要成果:
- 食物摄入概况表现出大量的个体和时间差异.
- 营养摄入量概况显示出随着时间的推移和不同个体的显著稳定性.
- 量化了"营养冗余"的概念,与嵌套的食物营养网络联系在一起.
- 营养冗余显示,与经典饮食分数相比,健康衰老的预测力相当.
- 较高的营养冗余与降低患心血管疾病和2型糖尿病的风险有关,无论年龄如何.
结论:
- 由于食品营养网络的营养冗余,提供了稳定的饮食质量的衡量标准.
- 这一措施是健康衰老的有价值预测指标,可以减轻主要慢性疾病的风险.
- 饮食评估可能受益于关注营养冗余,而不是仅仅关注食物摄入模式.
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