饮食中植物化学物质的潜在预防作用 In Vivo
Mai M Saleh1, Zeinab E Darwish2, Manal I El Nouaem2
1Lecturer Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. mai.mahmoud.dent@alexu.edu.eg.
BDJ open
|July 18, 2023
概括
绿茶和黄素对口腔癌具有显著的化学预防作用. 结合两种化合物可以提高它们在预防口腔致癌的有效性,提供了一个有前途的自然治疗策略.
科学领域:
- 在瘤学瘤学.
- 自然产品 化学 化学
- 预防医学 预防医学
背景情况:
- 化疗预防利用特定物质来抑制癌症的发展.
- 黄素 (来自Curcuma longa) 和儿茶素 (来自绿茶) 是强大的多.
- 作为绿茶中主要的多化合物之一的Epigallocatechin gallate与黄素具有协同作用.
研究的目的:
- 为了比较绿茶和黄素的化学预防作用,单独和组合.
- 为了评估它们对化学诱导的仓鼠口腔囊癌的影响.
主要方法:
- 使用了50只叙利亚金色仓鼠,分为五个组 (对照组,仅致癌物,绿茶,黄素,组合).
- 状细胞癌是化学诱导的.
- 用流式细胞计,免疫光和免疫组织化学来评估亡,增殖和血管生成.
- 使用ANOVA进行了统计分析.
主要成果:
- 与对照组相比,组合组显示出明显增加的亡.
- 绿茶和黄素治疗单独也增加了细胞亡.
- 细胞核中的红色光减少表明抑制了增殖.
- 与阳性对照组相比,治疗组的微血管密度明显较低.
结论:
- 绿茶和黄素的组合显示出对口腔致癌的显著化学预防作用.
- 这些天然化合物有望预防口腔癌.
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