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尿甲酸代谢物与美国青少年血清甲状腺功能之间的关联

Shi-Ting Xiang¹, Yuhan Cao^1,2, Jie Dong¹

¹Hunan Children's Research Institute (HCRI), Hunan Children's Hospital, Ziyuan RD 86, Changsha, 410007, China.

Scientific reports

|July 18, 2023

概括

暴露于酸盐混合物可能与美国青少年甲状腺功能变化有关. 这项研究发现了特定的酸盐和甲状腺激素之间的关联,这表明对青少年甲状腺健康的潜在影响.

科学领域:

环境健康环境健康
内分泌学在内分泌学.
毒理学毒理学毒理学

背景情况:

酸盐是常见的内分泌干扰化学物质,广泛暴露.
甲状腺功能对于青少年发育和整体健康至关重要.
关于甲酸盐暴露对青少年甲状腺功能的综合影响的研究有限.

研究的目的:

调查混合甲酸盐暴露与血清甲状腺功能指标之间的关联.
用美国青少年的数据分析这种关系.
评估甲酸盐混合物对甲状腺健康的影响.

主要方法:

利用了2007-2008年国家健康和营养检查调查 (NHANES) 的数据.
包括356名年龄在12-19岁的青少年.
使用加权多变量线性回归和贝叶斯核机回归 (BKMR) 分析.

主要成果:

线性回归表明了单一- ((carboxyisoctyl) 甲酸盐 (MCOP) 和总三甲氨酸 (TT3) 和甲状腺刺激激素 (TSH) 之间的正相关性.
单基酸 (MCNP) 显示与TSH的负相关性.
BKMR分析显示,甲酸代谢物混合物对TT3.3具有显著的积极总体效应.

结论:

混合甲酸盐暴露可能与美国青少年的血清TT3水平升高有关.
研究结果表明,甲酸盐混合物与甲状腺健康之间存在潜在的联系.
需要进一步的研究来理解这些关联的含义.

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