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鉴定循环单细胞作为结核病生物标志物C1qq的生产者

Paula Niewold¹, Douwe J Dijkstra², Yi Cai³

¹Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands. p.niewold@lumc.nl.

Scientific reports

|July 18, 2023

概括

研究人员确定单细胞是结核病患者补充成分C1q增加的来源. 这一发现有助于了解结核病生物标志物,并可能有助于诊断这种广泛传播的传染病.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
生物标志物发现发现

背景情况:

结核病 (TB) 是全球主要的健康问题,每年造成数百万人的死亡.
诊断结核病可能具有挑战性,特别是在资源有限的环境中.
补充成分C1q的血清水平升高是结核病的一个有希望的生物标志物,但其细胞起源仍然未知.

研究的目的:

确定负责生产循环中的补充成分C1q的特定细胞类型.
为了将C1q生产与不同的单细胞子集相关联.

主要方法:

对人类队列数据,临床试验和非人类灵长类动物研究的分析.
细胞子集频率与血清C1q水平的相关性.
单细胞RNA测序和流细胞计.

主要成果:

单细胞被确定为流通中的C1q的主要生产者.
经典和中间单细胞显示出明显的C1q表达.
非经典单细胞表现出可变的C1q表达.

结论:

单细胞是结核病患者C1q升高的来源.
了解C1q产生细胞可能会改进结核病诊断策略.
这项研究有助于结核病生物标志物开发领域.

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