在临床上没有损害的个体中,莱维体病理的认知影响
Sebastian Palmqvist1,2, Marcello Rossi3, Sara Hall1,2
1Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Nature medicine
|July 18, 2023
概括
临床前的勒维体 (LB) 病理会对认知产生负面影响,并与嗅觉受损有关. 同时发生的LB和阿尔茨海默病 (AD) 病理在症状出现之前加速个体的认知衰退.
科学领域:
- 神经退行性疾病的神经退行性疾病
- 神经病理学神经病理学
- 认知神经科学是一种认知神经科学.
背景情况:
- 列维体 (LB) 疾病的特征是α-synuclein聚合物.
- 临床前LB病理的影响,单独或与阿尔茨海默病 (AD) 病理 (β-粉样和) 一起,是不太了解的.
- 了解临床前的LB病理对于早期诊断和治疗策略至关重要.
研究的目的:
- 为了研究临床前的LB病理在认知不受损的个体的影响.
- 检查LB病理与AD病理 (Aβ和tau) 的关联.
- 确定LB病理对认知,嗅觉和疾病进展的影响.
主要方法:
- 使用大脑脊髓液α-synuclein种子放大试验.
- 分析了BioFINDER研究中的1,182名认知和神经学无损参与者的数据.
- 评估横断和纵向认知功能,包括全球认知,记忆和注意力/执行功能.
主要成果:
- 8%的参与者对LB病理学呈阳性.
- 与Aβ阳性相比,LB阳性更频繁,但与tau阳性相比,并非如此.
- 腰椎病理独立地影响认知,并与减少嗅觉有关;AD病理也影响了认知.
- 同时出现的LB和AD病理导致了更快的认知衰退.
- 只有LB阳性个体在10年内进展到临床LB疾病.
结论:
- 临床前的LB病理对认知和嗅觉有显著的独立负面影响.
- 同时存在的LB和AD病理会加剧认知衰退.
- 这些发现对于临床前临床LB疾病和早期AD的临床试验至关重要,为预后,招募和结果措施提供信息.
- 在临床前阶段早期发现LB病理对于疾病管理至关重要.
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