大脑和认知储备减轻多发性硬化症中平衡功能障碍
Luca Prosperini1, Irene Alcamisi2, Maria Esmeralda Quartuccio3
1Department of Neurosciences, S. Camillo-Forlanini Hospital, C.ne Gianicolense 87, 00152, Rome, Italy. luca.prosperini@gmail.com.
概括
大脑和认知储备保护多发性硬化症 (MS) 患者免受MS相关组织损伤引起的平衡问题. 较高的大脑体积和教育改善了平衡,特别是在执行需要注意力的任务时.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 人体生理学 人体生理学
背景情况:
- 多发性硬化症 (MS) 经常导致平衡功能障碍,影响日常生活.
- 然而,一些多发性硬化症患者保持平衡,尽管疾病负担很大,这表明有保护因素.
- 假设大脑和认知储备可以减轻MS相关组织损伤对平衡控制的影响.
研究的目的:
- 研究大脑和认知储备对MS相关组织损伤影响平衡的保护作用.
- 确定像内体积和教育程度这样的因素是否会影响MS中的平衡控制.
主要方法:
- 在148名多发性硬化患者和74名对照人群中,在双眼,闭眼和双重任务条件下使用强力平台测量了姿势摆动.
- 与MS相关的组织损伤通过病变体积和正常的大脑体积进行评估.
- 层次线性回归分析了内体积和教育成就对平衡的保护作用.
主要成果:
- 增加的内体积和更高的教育程度显著降低了MS相关组织损伤对双眼和双重任务条件下的姿势摆动的负面影响.
- 在闭眼条件下没有观察到这些保护作用.
- 教育水平和大脑大小都与闭眼时的姿势摇摆无关.
结论:
- 大脑和认知储备在MS患者的平衡中起着保护作用,支持运动和认知功能.
- 在闭眼条件下缺乏保护,表明这种平衡措施与脊髓完整性比脑损伤更密切相关.
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