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新的酸盐替代酸材料添加银离子作为潜在的抗真菌剂

Agata Piecuch¹, Sara Targońska², Justyna Rewak-Sorczyńska²

¹Department of Mycology and Genetics, University of Wrocław, Przybyszewskiego 63/77, Wroclaw, 51-148, Poland. agata.piecuch@uwr.edu.pl.

BMC microbiology

|July 18, 2023

概括

用银添加的酸酸盐 (HAp) 对各种酵母菌株具有显著的抗真菌活性. 这种新材料可以提供对手术感染的增强保护.

科学领域:

生物材料科学生物材料科学
材料化学材料化学
医学微生物学医学微生物学

背景情况:

酸酸盐 (HAp) 在骨置换和牙科植入物中至关重要.
提高HAp的生物相容性和抗菌特性是医疗应用的关键.
银离子表现出强大的抗菌和抗真菌活性,使它们成为HAp.有前途的兴奋剂.

研究的目的:

为了合成新型的酸盐替代酸 (HAp),添加银离子.
为了评估这些添加银的HAp材料对各种真菌菌株的抗真菌功效.
为了研究银离子度对抗真菌活性的影响.

主要方法:

用银离子合的酸盐替代酸 (HAp) 的水热合成.
用于晶体结构分析的X射线粉末衍射.
对Candida,Rhodotorula和Cryptococcus物种的抗真菌活性进行光谱光度评估.

主要成果:

合成的银离子合HAp材料具有不同的剂度 (0.7-2mol%).
即使是最低度 (0.7mol%Ag+) 在100μg/mL时也显著抑制了真菌生长.
抗真菌活性显示出株特异性差异,在较高的多邦剂水平或HAp度下没有进一步的抑制.

结论:

用银离子合的酸显示出显著的抗真菌特性.
这种Ag+离子-HAp材料具有作为减少手术部位感染的医疗剂的潜力.
进一步的研究可能会确定Ag+离子-HAp作为抗真菌医疗治疗中的一个有价值的成分.

关键词:

抗真菌剂是一种抗真菌剂.氧亚帕酸盐的氧亚帕酸盐机会主义的病原体.银离子是一种银离子.酵母酵母是一种酵母.

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