身体质量指数和部疾病之间的因果关系:双向的双样本孟德尔随机化分析
Xin Chen1, Zheng Cheng1, Junyu Xu1
1Department of Oral and Maxillofacial Surgery, Jiangyin People's Hospital Affiliated to Nantong University, No.163, Shoushan Road, Jiangyin, 214400, Jiangsu Province, China.
BMC oral health
|July 18, 2023
概括
下肢体质量指数 (BMI) 可能因果性地增加关节疾病 (TMD) 的风险. 这项门德尔随机化研究强调了体重管理对预防TMD的重要性.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 观察性研究表明,身体质量指数 (BMI) 和关节疾病 (TMD) 之间存在相关性.
- 以前的研究缺乏证据表明BMI和TMD之间存在因果关系.
- 门德尔随机化 (MR) 提供了一种使用遗传变异来调查因果关系的方法.
研究的目的:
- 调查身体质量指数 (BMI) 和部疾病 (TMD) 之间的潜在因果关系.
- 使用双向的门德尔随机化方法来评估两个方向的因果关系.
主要方法:
- 进行了两样双向孟德尔随机化分析.
- 使用全基因组关联研究 (GWAS) 的BMI (N=322,154) 和TMD (N=134,280) 的数据.
- 逆变量加权 (IVW),MR Egger和加权中位数方法用于因果效应估计,并进行了灵敏度分析.
主要成果:
- 前进的MR分析表明,基因预测较低的BMI与增加的TMD风险有关 (IVW OR:0.575,p=0.001).
- 反向MR分析显示TMD对BMI没有显著的因果作用 (p>0.05).
- 灵敏度分析证实了这些发现的稳定性,没有证据表明类或异质性.
结论:
- 较低的BMI可能是发展TMD的因果风险因素.
- 保持健康的体重对于预防TMD至关重要.
- 临床医生在评估患有关节不适的患者时应考虑BMI.
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