患有类风湿性关节炎和全身性硬化症的患者的认知功能低下和抑郁症状:一项临床研究
Panagiotis Alexopoulos1,2,3, Maria Skondra4, Marina Charalampopoulou4
1Mental Health Services, Department of Medicine, School of Health Sciences, Patras University Hospital, University of Patras, Rion 26504, Patras, Greece. panos.alexopoulos@upatras.gr.
BMC psychiatry
|July 18, 2023
概括
风湿性关节炎 (RA) 和系统性硬化症 (SSc) 患者经历认知缺陷,有时比轻度神经认知障碍 (MiND) 更严重. 这些障碍与抑郁症状有关.
科学领域:
- 类风湿病学 类风湿病学
- 神经心理学 神经心理学
- 精神病学是一个精神病学.
背景情况:
- 风湿性疾病中的认知缺陷正受到越来越多的关注.
- 类风湿性关节炎 (RA) 和系统性硬化症 (SSc) 的认知症状需要进一步调查.
- 了解RA和SSc的认知功能对于患者护理至关重要.
研究的目的:
- 评估RA和SSc患者的认知功能.
- 检查RA和SSc.的认知功能和抑郁症状之间的关系.
- 为了比较RA和SSc患者轻度神经认知障碍 (MiND) 和认知健康个体的认知表现.
主要方法:
- 使用认知电话查仪器加 (COGTEL+),连续七测试 (SST) 和迷你精神状态检查 (MMSE) 评估认知功能.
- 用老年抑郁症尺度-15 (GDS) 测量抑郁症状.
- 统计分析包括组比较,相关性和回归分析,控制人口统计数据.
主要成果:
- 与对照人群相比,RA患者在口头短期记忆,集中/注意力,口头流利和MMSE方面表现较差.
- 在口头流利,集中/注意力,诱导推理和MMSE方面,RA患者的表现比MiND患者差.
- SSc患者表现出口语流性和MMSE的缺陷,超过MiND中所见的缺陷,这些缺陷与GDS得分有关.
结论:
- 类风湿性关节炎和系统性硬化症患者经历认知功能障碍.
- 抑郁症状部分导致观察到的认知缺陷.
- 在RA和SSc患者中,认知功能障碍的严重程度可以超过轻度神经认知障碍.
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