膀癌患者条件生存的种族差异:一个基于人口的研究
Wei Liu1,2,3, Jie Xiong1,2, Honghao Wang1,2
1Department of Urology, Aerospace Center Hospital, Beijing, China.
BMC urology
|July 18, 2023
概括
患有膀癌的非裔美国人最初的生存率较差,但在几年后,他们与白人和亚洲/太平洋岛屿患者的结果相似. 随着生存时间的增加,种族对预后的预测力变得不那么强.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 传统的癌症预测结果是静态的,不考虑种族的不断变化的影响.
- 评估动态生存对于理解膀癌预后的种族差异至关重要.
研究的目的:
- 为了揭示膀癌患者的动态生存模式.
- 探索种族对膀癌患者预后的影响.
主要方法:
- 利用来自SEER注册表的110,371名膀癌患者 (白人,非裔美国人,亚洲/太平洋岛民) 的数据.
- 使用卡普兰-梅尔算法估计的条件癌症特异性生存率 (CSS).
- 通过多变量考克斯回归与条件生存 (CS) 估计,评估了种族对生存的不断变化的影响.
主要成果:
- 非洲裔美国患者随着时间的推移显示出CSS的改善,在4年后达到与白人和API患者相当的水平.
- 随着时间的推移,在所有种族群体和患者子集中观察到改善生存率的趋势.
- 非洲裔美国人的死亡风险随着生存时间的增加而降低,在4年后,在统计学上与白人患者相似.
结论:
- 尽管最初的生存率较差,但患有膀癌的非裔美国人可以与其他种族群体相比实现长期生存.
- 随着膀癌患者的生存时间的增加,种族对预后较差的预测能力减少.
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