慢性鼻炎与鼻息肉患者的并发性喘:dupilumab是否有所不同?
Mona Al-Ahmad1,2, Asmaa Ali3,4,5, Mustafa Khalaf3
1Department of Microbiology, College of Medicine, Kuwait University, Kuwait City, Kuwait. mona.alahmad@ku.edu.kw.
BMC pulmonary medicine
|July 18, 2023
概括
杜皮卢马布有效地改善了慢性鼻炎与鼻息肉 (CRSwNP) 的患者的生活质量和嗅觉症状,即使是那些患有并发性喘患者. 这种生物疗法还增强了喘症状控制,证明了广泛的疗效.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性鼻炎 (CRS) 和支气管喘由于不同的炎症概况而表现出临床异质性.
- 在CRSwNP和喘中共享的2型炎症表明,单一的生物疗法对这两种疾病都有潜在的疗效.
- 有限的现实世界数据存在于dupilumab对患有或没有喘的CRSwNP患者的生活质量和症状的影响.
研究的目的:
- 评估dupilumab对CRSwNP患者嗅觉症状和与健康相关的生活质量 (SNOT-22) 的影响.
- 评估dupilumab对CRSwNP和并发性喘患者的喘症状控制 (ACT) 的影响.
主要方法:
- 一项前性研究涉及166名被诊断患有CRSwNP的患者,有或没有喘.
- 在基线和六个月后收集的数据包括SNOT-22得分,嗅觉症状频率和ACT得分.
- 分析对CRSwNP患有喘和没有喘患者的结果进行了比较.
主要成果:
- 在CRSwNP队列中,喘患病率很高 (59.63%).
- 女性性别,先前使用口服皮质类固醇和先前手术等因素增加了喘的可能性.
- 杜皮卢马布改善了所有患者的生活质量和嗅觉症状,无论喘状况如何,尽管喘患者需要更长时间的治疗.
结论:
- 杜皮卢马布显著改善了CRSwNP患者的生活质量和嗅觉症状.
- 该疗法还有效控制了伴随性喘患者的喘症状.
- 杜比卢马布为管理CRSwNP提供了一种有价值的治疗选择,即使存在喘.
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