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Updated: Jul 23, 2025

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DNMT3A突变通过NAM-NAD代谢重编程促进白血病的发展

Xuejiao Yang1, Xiao Wang1, Ying Yang1

  • 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Journal of translational medicine
|July 18, 2023
PubMed
概括

在DNMT3A的突变驱动急性髓性白血病 (AML) 通过调节NAMPT,破坏NAD代谢和加速细胞循环. 向NAMPT为具有DNMT3A突变的AML提供了潜在的代谢疗法.

关键词:
在AML,AML就是AML.在DNMT3A突变中.代谢重编程是一种代谢重编程.NAM-NAD代谢的代谢方式这个名字叫做NAMPT.

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