混合迪克洛菲纳克溶液对根运河生物膜的有效性
Carmen Maria Ferrer-Luque1,2, Carmen Solana2, Beatriz Aguado3
1Department of Stomatology, School of Dentistry, University of Granada, Granada, Spain.
概括
迪克洛菲纳克溶液,特别是添加了 cetrimide (CTR),有效地对抗多微生物根管生物膜. 在这项研究中,较高度的迪克洛菲纳克和塞特里米德显示出更高的抗菌活性.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 微生物学 微生物学
- 生物材料科学 生物材料科学
背景情况:
- 根管中的多微生物生物膜在内牙治疗中构成了重大挑战.
- 有效地根除这些生物膜对于成功的内牙治疗至关重要.
- 狄克洛菲纳克和塞特里米德正在研究它们的潜在抗菌性质.
研究的目的:
- 评价用或不含 cetrimide (CTR) 的二芬溶液对多微生物根管生物膜的疗效.
- 为了比较不同度的二克洛芬酸盐和 cetrimide 组合的抗菌活性.
- 评估 cetrimide 对二克洛芬纳克抗菌膜疗效的影响.
主要方法:
- 多微生物根管生物膜在牙样本上生长.
- 治疗组包括不同度的二二 (DCS) 和 cetrimide (CTR),以及盐水对照组.
- 在接触5分钟后,使用腺三酸盐 (ATP) 测定和共聚焦激光扫描显微镜 (CLSM) 评估了抗菌活性.
主要成果:
- 含有5%二甲 (DCS) 和2.5%DCS和0.4%CTR的溶液表现出最高的抗菌疗效.
- 塞特里米德显著增强了二二的抗菌膜活性.
- 两种ATP测定 (RLU减少) 和CLSM (生物体积,生存能力) 都证实了这些组合的优越性能.
结论:
- 狄克洛芬纳克,特别是在较高度和与 cetrimide 结合使用时,对多微生物根管生物膜有效.
- 塞特里米德作为增强剂,在内牙科应用中增加了二甲的抗菌膜潜力.
- 这些发现表明一种有希望的治疗方法来治疗内牙生物膜感染.
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