系统性免疫炎症指数与新诊断的高血压患者的逆浸水昼夜模式之间的关系
Muammer Karakayali1, Timor Omar1, Inanç Artac1
1Department of Cardiology, Kafkas University School of Medicine, Kars, Turkey.
系统性免疫炎症指数 (SII) 可以预测新诊断的患者的逆滴高血压. 更高的SII水平表明更大的风险,作为这种特定血压模式的早期预警.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 高血压研究 高血压研究
背景情况:
- 昼夜血压 (BP) 模式受损与不良的临床结果有关.
- 系统性免疫炎症指数 (SII) 由血液细胞计数得出的,是心血管疾病的预后标志物.
- 炎症在高血压的发病过程中起作用,并与血压变化有关.
研究的目的:
- 研究新诊断高血压患者的昼夜血压变化与SII之间的关联.
- 确定SII是否可以预测特定的昼夜血压模式,特别是反向浸泡模式.
主要方法:
- 对196名新诊断的高血压患者没有左心室缩 (LVH) 的分析.
- 根据24小时的门诊血压监测,将患者分为低血压,低血压和反向低血压血压模式.
- 多变量物流回归和ROC曲线分析,以确定反向浸泡模式的预测因素,并确定SII截止值.
主要成果:
- 该研究确定了76个浸泡器,60个不浸泡器和60个反向浸泡器.
- 多变量分析显示,SII和HDL-C是反向浸泡昼夜血压模式的独立预测因素.
- 一个SII截止值>639.73显示了63.3%的灵敏度和84.2%的特异性来识别反向入者.
- 反向浸泡组的平均SII水平与浸泡组和非浸泡组相比显著更高.
结论:
- 升高的SII与新诊断的高血压患者的逆浸水昼夜血压模式有关.
- SII是反向浸泡模式的独立预测器,表明其在风险分层中的实用性.
- 高的SII水平可以作为早期预警参数,用于识别患有逆升高血压的人,并可能指导早期干预策略.
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