同时发生的胆结石病与在接受乌尔索氧胆酸治疗的患有原发性胆道胆炎的患者的长期结果没有关联
Sha Chen1, Meng Qi Li1, Bu Er Li1
1Liver Research Center, Beijing Friendship Hospital, Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Diseases, Beijing, China.
Journal of digestive diseases
|July 19, 2023
概括
胆结石病 (GD) 在中国的初级胆道胆炎 (PBC) 患者中很常见. 然而,这项研究发现,GD不会对用ursodeoxycholic acid治疗的PBC患者的长期预后产生负面影响.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 初级胆道胆炎 (PBC) 是一种罕见的自身免疫性肝病.
- 胆结石病 (GD) 是一种常见的疾病.
- 特别是在中国,GD和PBC预后之间的关系尚不清楚.
研究的目的:
- 为了确定胆结石病 (GD) 在中国患者中患有原发性胆道胆道炎 (PBC) 的患病率.
- 为了研究同时出现的胆结石病 (GD) 对 Ursodeoxycholic 酸治疗的初级胆道胆炎 (PBC) 患者的长期预后的影响.
主要方法:
- 医疗记录的回顾性审查和结构化的电话采访,以获得后续数据.
- GD的定义:在超声波检测中出现胆结石或有胆囊切除病史.
- 使用倾向分数匹配 (PSM) 和考克斯回归分析来评估结果.
主要成果:
- 总共有985名PBC患者被纳入;26.2%的人患有GD.
- 患有GD的患者年龄较大,有更多的2型糖尿病,在基线时有更严重的肝病.
- 在PSM后,在有或没有GD的PBC患者之间没有观察到无移植生存或肝病发作的显著差异.
结论:
- 同时发生的胆结石病 (GD) 在中国的ursodeoxycholic acid治疗的初级胆道胆炎 (PBC) 患者中很普遍.
- 没有发现胆结石病 (GD) 是该患者队列中长期不良结果的独立风险因素.
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