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Updated: Jul 23, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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氨酸扫描突变体αO-Conotoxins GeXIVA[1,2]和GeXIVA[1,4]的结构活动关系

Pan Xu1,2, Panpan Zhang1, Xiaopeng Zhu1

  • 1School of Medicine, Guangxi University, Nanning 530004, China.

Journal of medicinal chemistry
|July 19, 2023
PubMed
概括

阿尔法-O-毒素GeXIVA异构体抑制alpha9alpha10尼古丁性乙烯基胆受体 (nAChRs). 氨酸扫描揭示了关键相互作用,表明这些强大的 analgesic 候选人的全结合而不是正结合.

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