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手持设备量化呼吸中的乙,用于现实生活中的代谢健康监测

Grégoire M G B H Bastide^1,2, Anna L Remund^1,2, Dina N Oosthuizen^1,3

¹Particle Technology Laboratory, Department of Mechanical and Process Engineering, ETH Zurich CH-8092 Zurich Switzerland iweber@ethz.ch.

Sensors & diagnostics

|July 19, 2023

概括

一个新的便携式设备可以快速,非侵入性地监测呼吸中的乙. 这种燃烧脂肪的生物标志物可以指导个性化的生活方式变化和代谢疾病治疗.

科学领域:

生物医学工程生物医学工程
分析化学分析化学
移动健康服务提供者

背景情况:

非侵入性呼吸分析为个性化健康管理提供了潜力.
呼吸中的乙是脂肪代谢的关键生物标志物,与代谢疾病相关.
现有的呼吸中乙检测方法可能很麻烦或缺乏可移植性.

研究的目的:

开发和验证一种简单的手持设备,用于快速和选择性地检测出口气中的乙.
评估设备在饮食和运动干预期间跟踪呼吸中乙水平的性能.
与黄金标准分析技术相比,为了确定设备的稳定性和准确性.

主要方法:

设计了一个便携式设备,集成了一个呼吸采样单元,催化波器,分离柱和传感器.
该设备使用Raspberry Pi微控制器进行操作,并通过触摸屏显示数据.
呼吸中乙度被测量在接受基因饮食和运动的志愿者身上,与PTR-ToF-MS.相比验证.

主要成果:

该设备准确地测量了基因饮食志愿者的呼吸中乙度,高达26.3ppm.
它成功地检测出与基线和运动相关的小酸盐变化 (低至0.5ppm).
该设备在四个多月的时间里表现出稳定性,偏差极好,精度低于5ppm.

结论:

开发的手持设备提供了一种简单,非侵入性和准确的方法,用于例行呼吸乙监测.
这项技术有望指导治疗方法和个性化改变与代谢健康相关的生活方式.
该设备的便携性和易用性使得在临床环境之外的实时健康跟踪更容易.

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