肺癌风险的分层与胸部成像表型的肺癌风险
Kaiwen Xu1, Mirza S Khan2, Thomas Li1
1Vanderbilt University, 2201 West End Ave, Nashville, TN, USA 37235.
概括
从肺癌查CT扫描中确定的身体习惯或身体形状可以预测未来的肺癌风险. 这种使用成像表型的新方法可能会改善风险分层,超越传统因素,如吸烟状况.
科学领域:
- 放射学和医学成像学 医学成像学
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 目前的肺癌风险模型主要使用人口统计和吸烟情况.
- 身体习惯对肺癌风险的影响是公认的,但未被纳入预测模型.
- 胸部低剂量计算机断层扫描 (LDCT) 提供详细的胸部成像,包括身体组成和器官排列.
研究的目的:
- 为了研究使用胸部LDCT来表型身体习惯的可行性.
- 为了确定这些基于图像的身体习惯表型是否可以增强肺癌风险分层.
- 评估已识别的表型对未来肺癌发病率的预测能力.
主要方法:
- 在空间规范化的LDCT图像上使用对对不相似度指标构建了一个胸部成像多元组.
- 应用了等级聚类来识别不同的身体习惯表型.
- 在国家肺部查试验中的1200名男性受试者中,使用时间到事件分析将确定的表型与未来肺癌风险联系起来.
主要成果:
- 确定了五种不同的主要表型,每个都有独特的临床和身体息特征.
- 这五种表型中有两种与未来肺癌风险升高有显著关联 (HRs在1.61至1.67之间).
- 鉴定的表型显示出可区分的特征和肺癌风险的预测价值.
结论:
- 基于图像的身体习惯的表型从肺查LDCT是可行的.
- 来自LDCT扫描的身体习惯表示可能会增强当前的肺癌风险分层模型.
- 这种方法为个性化肺癌风险评估提供了一种新的成像生物标志物.
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