斯坦丁治疗对肌病的发展的影响:全国性基于人口的队列研究
Donghee Kwak1, Seok-Joo Moon2, Jong Woong Park1
1Department of Orthopedic Surgery, Korea University Anam Hospital, Seoul, Republic of Korea.
Orthopaedic journal of sports medicine
|July 19, 2023
概括
静止剂使用增加了发展肌病的风险,但较高的累积剂量可能会降低这种风险. 这项研究澄清了他类药物与倾向性病变的联系.
科学领域:
- 心血管研究研究心血管研究
- 药物监督 药物监督 药物监督
- 肌肉骨系统疾病 肌肉骨系统疾病
背景情况:
- 关于他类药物的使用和肌病的发展存在相互矛盾的结果.
- 类药物类型和累积剂量对肌病风险的具体影响尚不清楚.
研究的目的:
- 调查他类药物治疗与肌病障碍的发生率之间的关联.
主要方法:
- 一项全国性的基于人口的队列研究包括了2002年至2015年的594,130名参与者.
- 倾向性得分匹配确定了84,102名他类药物使用者和168,204名非使用者.
- 考克斯的比例危险模型分析了他类药物使用与五种肌病变之间的关联.
主要成果:
- 斯坦丁使用与所有肌病类型的更高风险显著相关 (HR, 1.435).
- 随着累计他类药物剂量增加,观察到一种降低风险的趋势.
- 累计剂量为90,91-180和每日定义剂量>180的危险比分分别为2.337,2.210和1.1.
结论:
- 不管类型如何,使用他类药物,与不使用者相比,增加了肌病变的风险.
- 增加累积的他类药物剂量似乎可以减轻肌病发展的风险.
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