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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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种族差异和有助于心血管和非心血管风险因素导致慢性病进展
Yuni Choi1, David R Jacobs1, Holly J Kramer2
1Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Vascular health and risk management
|July 19, 2023
概括
黑人美国人经历慢性病 (CKD) 的进展速度比白人美国人快. 肺功能 (FVC),高血压和肥胖症部分解释了CKD进展中的这些种族差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 心血管研究研究心血管研究
背景情况:
- 晚期慢性病 (CKD) 与白人美国人相比,不成比例地影响黑人美国人.
- 新兴研究表明,器官间的交叉交谈,特别是肺功能和脏之间的交谈,可能会导致CKD进展的种族差异.
研究的目的:
- 为了评估黑人和白人参与者之间CKD进展的差异.
- 确定包括肺功能在内的生物风险因素对观察到的CKD进展中的种族差异的贡献.
主要方法:
- 一项对2175名黑人和2207名白人的纵向研究,来自冠状动脉风险发展在年轻成年人 (心脏病) 队列.
- 测量了20年间估计的淋巴膜过率 (eGFR) 和尿中的白蛋白与肌素比率 (UACR),以对慢性病风险进行分类.
- 利用多变量调整的考克斯模型来评估种族,CKD进展和风险因素之间的关联.
主要成果:
- 黑人参与者在20年内表现出更高的CKD过渡概率和更普遍的风险因素.
- 黑人参与者在所有阶段中,CKD进展的危险比率显著更高.
- 对于从没有CKD过渡到低风险CKD,强迫生命能力 (FVC),高血压和肥胖症分别解释了54.8%,30.9%和20.8%的种族差异.
结论:
- 与白人相比,黑人人面临着更高的CKD进展风险.
- 强迫性生命能力 (FVC) 和常规风险因素部分解释了在CKD进展中观察到的种族差异.
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