发光体-ER膜接触点的组织和功能
Prado Vargas Duarte1, Fulvio Reggiori1,2
1Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Contact (Thousand Oaks (Ventura County, Calif.))
|July 19, 2023
概括
宏自性涉及形成自细胞的自细胞,需要在ER膜接触部位获取脂质. 这篇综述详细介绍了ATG9,ATG2和WIPI4蛋白质.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 宏自是一种细胞过程,通过自细胞通过自细胞来降解受损的组件.
- 自细胞生物发生需要脂质的获取,以使细胞扩张.
- 胞膜接触部位 (MCSs) 与内分泌网膜 (ER) 对脂质供应至关重要.
研究的目的:
- 审查目前对ATG9,ATG2和Atg18/WIPI4蛋白质在宏观自中的理解.
- 为了阐明这些蛋白质在phagophore-ER MCSs中的功能性相互关系.
- 要突出它们在巴哥扩张和脂质获取中的作用.
主要方法:
- 最近的体内和体外研究的文献综述.
- 分析蛋白质结构,相互作用和定位.
- 专注于酵母菌Saccharomyces cerevisiae和哺乳动物系统.
主要成果:
- 保存的ATG蛋白质,包括ATG9 (脂质混杂酶),ATG2 (脂质转移) 和Atg18/WIPI4 (β-螺旋),集中在孔-ER MCS中.
- 这些蛋白质对于脂质供应至关重要,驱动着孔扩张.
- 已经取得了重要的概念进步,但功能细节仍在调查中.
结论:
- ATG9,ATG2和Atg18/WIPI4蛋白质在自细胞生物发生过程中发挥着关键的,相互关联的作用.
- 了解它们在MCS中的精确功能是了解自过程中的脂质动态的关键.
- 需要进一步的研究才能充分阐明它们的分子机制.
相关概念视频
Assembly of the Lipid Bilayer in the ER
3.2K
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
3.2K
Phagocytosis
81.7K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
81.7K
The Endoplasmic Reticulum
14.9K
The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
14.9K
Introduction to Membrane Traffic
7.2K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
7.2K
Receptor-mediated Endocytosis
104.7K
Overview
104.7K
ER Retrieval Pathway
3.9K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
3.9K


